Data describing the association between rs266729 polymorphism inadiponectin promoter gene and Type 2 Diabetes Mellitus
نویسندگان
چکیده
This article investigates whether there is an association between the rs266729 polymorphism in adiponectin promoter gene with metabolic parameters and disease status in 300 type 2 diabetes patients and 300 healthy adults from Jahrom city, Iran. The variants (G/C) were tested by polymerase chain reaction-restriction fragment length polymorphism method (RFLP) and metabolic parameters (glucose, cholesterol, HDL and LDL cholesterol) were measured using biochemical methods. However, no differences were detected between the haplotypes investigated, and the data obtained from our lab shown association of the ADIPOQ promoter polymorphism neither with biochemical parameters, nor with disease status.
منابع مشابه
The Soluble Carrier 30 A8 (SLC30A8) Gene Polymorphism and Risk of Diabetes Mellitus Type 2 in Eastern Azerbijan Population of Iran
Type 2 Diabetes Mellitus (T2D) is the most common metabolic disease demonstrating itself by hyper- glycemia, due to impaired insulin secretion or action. Recently, Whole-Genome Association studies have revealed the role of several new genes responsible for T2D. One of the most studied genes is SLC30A8 (Zn-T8) which is exclusively expressed in pancreatic ?-cells and participates in insulin stora...
متن کاملAssociation of adiponectin gene rs2241766 polymorphism with serum adiponectin level, Insulin resistance and type 2 diabetes mellitus in an Iranian population
Introdution: Adiponectin is a peptide secreted from fat cells that plays an important role in the development of insulin resistance and type 2 diabetes. A number of single nucleotide polymorphisms in the adiponectin gene are associated with lower adiponectin expression and T2DM. The aim of this study was to determination the frequency of rs 2241766 polymorphism in adiponectin gene and its relat...
متن کاملASSOCIATION ANALYSIS BETWEEN RS10830962 VARIANT OF MTNR1B GENE AND TYPE 2 DIABETES MELLITUS RISK
Background: Type 2 diabetes mellitus (T2DM) is the most common type of diabetes that was classically characterized by pancreatic β-cell dysfunction. Changes in circadian patterns is one of the reasons which can increase the occurrence of diabetes. Melatonin is one of the biological molecules which plays an important role in regulating the circadian clock and also an inhibitory effect on insulin...
متن کاملAssociation of IFN-¹ Gene Polymorphism with Type 1 Diabetes in Iranian Patients
Background: Type 1 Diabetes (T1D) is a chronic and progressive autoimmune disorder. Cytokines play a critical role in the pathogenesis of T1D. Objective: IFN-¹ polymorphism was investigated in T1D and compared with normal controls. Methods: Thirty patients suffering from T1D and 40 normal controls were studied simultaneously using PCR technique. IFN- ¹ gene was evaluated at position 5’UTR...
متن کاملبررسی ارتباط بین پلیمورفیسم A ۲۵۴8-G در پروموتر ژن لپتین با سطح لپتین پلاسما و استعداد ابتلا به دیابت نوع 2
Introduction: Leptin, the obese (ob) gene product, is a cytokine-like hormone secreted mainly from adipose tissue acting on a receptor site in the hypothalamus to inhibit food intake and stimulate energy expenditure. A G-2548G polymorphism in the leptin gene promoter has a strong influence on leptin gene expression and adipose tissue secretion. The aim of this study was to examine the associati...
متن کامل